NSF RII Track-1: ND-ACES

National Science Foundation (NSF)
EPSCoR Research Infrastructure Improvement (RII) Track-1 Awards:
2020-2025 NSF EPSCoR Track-1 Cooperative Agreement, $20 million, Award Number 1946202
Principal Investigator (PI): Kelly A. Rusch, Ph.D., P.E., BCEE; NDSU
Co-PIs: John Mihelich, Ph.D.; UND and Jean Ostrom-Blonigen, Ph.D., CPA; ND EPSCoR

New Discoveries in the Advanced Interface of Computation, Engineering, and Science (ND-ACES)

ND-ACES: New Discoveries in the Advanced Interface of Computation, Engineering, and Science (ND-ACES), ND EPSCoR’s most recent NSF RII, is a five-year cooperative agreement that carries an 80/20% federal/state match.

Research Center: Center for Cellular Biointerfaces in Science and Engineering (CCBSE)

Broader Impacts: PROmoting Sustainable Partnerships in Education and Research (PROSPER)

In addition to the funding the research activities of the CCBSE, ND-ACES researchers at the 10 participating campuses are eligible to compete for additional funding opportunities. View the ND-ACES funding opportunity awardees.

Participant Institutions

Impact

Building on strategic NSF and ND investments made since ND EPSCoR began, ND-ACES is:

  • Working collaboratively within the Center for Cellular Biointerfaces in Science and Engineering (CCBSE).
  • Fostering critical research infrastructure.
  • Integrating research, education, and human resources with workforce development initiatives to strengthen the state’s overall research competitiveness. The collective impact has been active involvement in research, outreach, education, and broadening participation activities throughout the state. PROSPER (PROmoting Sustainable Partnerships in Education and Research) is the broadening participation arm of ND-ACES and is fully integrated with the corresponding efforts of the CCBSE.

The ten participating institutions include one master's college/university (MCU), three primarily undergraduate institutions (PUI), four tribal colleges/universities (TCU), and two research universities (RU).

Center for Cellular Biointerfaces in Science and Engineering (CCBSE)

ND-ACES will expand capacity by leveraging investments to generate new knowledge and increase North Dakota's competitiveness in biosciences by working collaboratively within the Center for Cellular Biointerfaces in Science and Engineering (CCBSE). The CCBSE has three pillars of scientific inquiry: materials design at biointerfaces; cellular systems at materials interface; and computation, machine learning, and predictive modeling. The CCBSE is also linked to ND-ACES outreach arm, Promoting Sustainable Partnerships in Education and Research (PROSPER). The CCBSE is co-led by NDSU University Distinguished Professor Kalpana S. Katti, Ph.D., F. AIMBE and UND Chester Fritz Distinguished Professor Colin K. Combs, Ph.D.

Materials Design at Biointerfaces Pillar

Led by Sanku Mallik (NDSU) and Julia Xiaojun Zhao (UND). Team members: Austin Allard (TMCC), Mikhail Bobylev (Minot State), Guodong Du (UND), Khwaja G. Hossain (Mayville State), Kalpana S. Katti (NDSU), Mike Parker (CCCC), Mohiuddin Quadir (NDSU), Binglin Sui (UND), Brent Voels (CCCC), Wenjie Xia (NDSU), Yongki Choi (Emerging Areas Seed Awardee; NDSU), Michael Kjelland (Emerging Areas Seed Awardee; Mayville State), Danling Wang (Emerging Areas Seed Awardee; NDSU), and Ali Alshami (Emerging Araes Seed Awardee; UND).

The Materials Design at Biointerfaces Pillar objective is to progressively increase CCBSE researcher knowledge and application in the area of biomaterial scaffolds relevant to tissue engineering, particularly in the area of design methodologies of biologically inspired materials for diverse 3D tissue architectures.

Cellular Systems at Materials Interface Pillar

Led by Archana Dhasarathy (UND) and John C. Wilkinson (NDSU). Team members: Colin K. Combs (UND), Guodong Du (UND), Nicholas Galt (VCSU), Amanda Haage (UND), Kerry Hartman (NHSC), Kalpana S. Katti (NDSU), Jiha Kim (NDSU), Hilde van Gijssel (VCSU), Motoki Takaku (Emerging Areas Seed Awardee; UND), Xusheng Wang (Emerging Areas Seed Awardee; UND), Stefan Vetter (Emerging Areas Seed Awardee; NDSU), and Estelle Leclerc (Emerging Areas Seed Awardee; NDSU).

The Cellular Systems at Materials Interface Pillar objective is to increase the capacity and expertise of the CCBSE researchers in basic and translational use of in vivo-like 3D cell cultures, which will ultimately (long-term outcome) allow the team to partner with regional health care providers to serve as a resource for personalized medicine approaches to cancer.

Computation, Machine Learning, and Predictive Modeling Pillar

Led by Dinesh R. Katti (NDSU) and Mark Hoffmann (UND). Team members: Deniz Cakir (UND), Jerome Delhommelle (UND), Marcus Fries (DSU), Svetlana Kilina (NDSU), Trung Bao Le (NDSU), Lu Liu (NDSU), Wenjie Xia (NDSU), Ravi Kiran Yellavajjala (Emerging Areas Seed Awardee; NDSU), Manu (Emerging Areas Seed Awardee; UND), and Yen Lee Loh (Emerging Areas Seed Awardee; UND). Support for this pillar will come from the high performance computing centers at NDSU (Khang Hoang) and UND (Aaron Bergstrom).

The Computational Approaches Pillar objective is to enhance connected learning, knowledge, and application across multi-scale modeling, machine learning platforms, and experimental biomaterials and cellular data, which will result in an evolutionary in-silico platform to predict tumor growth. Increased knowledge and understanding of 3D systems can lead to future therapeutic/mitigation alternatives.

 

PROmoting Sustainable Partnerships in Education and Research (PROSPER)

PROSPER, the broadening participation arm of ND-ACES, will provide education and experiences designed to build a diverse workforce, enhance partnerships and collaborations with various stakeholders, and inform ND’s residents. The four elements of PROSPER are:

Education and Workforce Development

Led by Rachel L. Navarro and Sarah Sletten (both UND) and co-led by Jean Ostrom-Blonigen (ND EPSCoR), this initiative supports faculty professional development, student training, and K-12 student bioscience, engineering, and computational exposure.Team member: Ryan G. Summers (UND).

Broadening Participation

Led by Van Doze (UND) and co-led by Jean Ostrom-Blonigen (ND EPSCoR), this initiative supports American Indian students along the biosciences pathway. Team members include the TCU NATURE Coordinators: Austin Allard (TMCC), Brent Voels (CCCC), Kerry Hartman (NHSC), and Mafany Ndiva Mongoh (SBC).

Partnerships and Collaborations

Led by Kelly A. Rusch (NDSU) and co-led by John Mihelich (UND) and Jean Ostrom-Blonigen (ND EPSCoR), this initiative builds research infrastructure and strengthens ND’s research competitiveness through industry partnerships and other collaborations. Team members include the CCSBE leadership. View the Partnerships and Collaborations Year One Review and Year Two Plan document here.

Communication and Dissemination

Led by Zoltan P. Majdik (NDSU) and co-led by Cailin Shovkoplyas (ND EPSCoR), this ND-ACES wide initiative keeps all stakeholders informed; supports the harmonious interactions of all ND-ACES groups; assists research and programmatic participants in disseminating their work to legislative, scientific, and citizen stakeholders; and develops materials for consumption by lay audiences.

Track-1 Strategic Plan

Original NSF Approval: October 19, 2020

1st Revision: February 18, 2021 (NSF approves change in senior personnel)

2nd Revision: March 9, 2021 (NSF approves change in Education and Workforce Development Activities)

3rd Revision: July 28, 2021 (NSF approves change in senior personnel, addition of ND-ACES new hire at UND, and changes in Materials Design and Cellular Systems activities and assignments. This revision also records recent changes in the ND EPSCoR State Steering Committee membership)

4th Revision: August 27, 2021 (NSF approves changes in senior personnel, Education and Workforce Development Activities, and mandatory meeting structure)

5th Revision: September 8, 2021 (NSF approves changes in senior personnel)

6th Revision: October 18, 2021 (NSF approves change in senior personnel)

Attached file here


 

NSF RII Track-1 ND-ACES External Advisory Board

The NSF RII Track-1 ND-ACES External Advisory Board (EAB) is composed of individuals from universities and organizations across the country who provide insight and support for the current Track-1 effort.

Candan Tamerler, Ph.D., EAB Chair

Associate Dean of Research
School of Engineering
Wesley G. Cramer Professor
Department of Mechanical Engineering
University of Kansas
Lawrence, KS

Tejal Desai, Ph.D. EAB Vice Chair

Ernest L. Prien Endowed Professor and Chair
Bioengineering & Therapeutic Sciences Department
School of Pharmacy
University of California - San Francisco
San Francisco, CA

Marc D. Basson, M.D., Ph.D., M.B.A., F.A.C.S.

Senior Associate Dean for Medicine and Research
Professor of Surgery, Pathology, and Biomedical Sciences
UND School of Medicine & Health Sciences
Grand Forks, ND

James Brown, Ph.D.

CEO and President
Agathos Biologics
West Fargo, ND

Sinan Keten, Ph.D.

Professor of Mechanical Engineering and Civil and Environmental Engineering and (by courtesy) Biomedical Engineering
June and Donald Brewer Professor
Northwestern University
Evanston, IL

Annalies Corbin, Ph.D.

President & CEO
The PAST Foundation
Columbus, OH

David Pearce, Ph.D.

President of Innovation and Research
Sanford Research
Sioux Falls, SD

Daniel M. Tuvin, M.D., F.A.C.S.

Surgical Oncologist
Sanford Health
Fargo, ND


Acknowledgment

The Track-1 is a federal-state partnership to manage a comprehensive research development plan. ND EPSCoR manages the Track-1 award. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. Current funding is provided by the State of North Dakota and NSF EPSCoR Research Infrastructure Improvement Program Track-1 (RII Track-1) Cooperative Agreement Award OIA #1946202.